So why, then, am I one of three cousins (out of a total of 20+, the other two being my full-blood siblings) that can have more than a glass of wine without getting sick and/or falling asleep? And did you know that Israel has one of the lowest incidences of alcoholism in the world?
It's likely because of a genetic mutation called ADH2*2, which increases the levels of acetaldehyde in your blood stream. Acetaldehyde is a toxic chemical produced when your body metabolizes alcohol - and it causes some pretty nasty effects like headaches, nausea, and flushing ("glow"). Though not exclusive to the Jewish population, about 20% of Jews have this mutation, and the effects are strongest for Ashkenazi Jews (aka my family).
This mutation is very rare among those with white European descent. Fortunately for my wine-drinking habits, my father is 100% not Jewish, with a Certified Eastern European Liver (pretty sure that's the official scientific term for someone as far away from the ADH2*2 mutation as possible). I confirmed with the 23andMe test that I do not have this mutation, and process alcohol normally.
Thank goodness, and l'chaim!
No comments:
Post a Comment